State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
Sci Total Environ. 2015 Feb 15;506-507:58-65. doi: 10.1016/j.scitotenv.2014.10.117. Epub 2014 Nov 15.
Trimethoprim (TMP) and sulfamethazine (SMZ) are two antibiotics that are often administered in combination. We investigated the sorption and desorption behaviors of TMP and SMZ individually as single solute and in combination as co-solute in three representative soils, and evaluated joint antibacterial activity of the soil-adsorbed antibiotics to a reference strain Escherichia coli ATCC 25922. Comparative sorption tests showed that co-solute sorption of TMP and SMZ was not considerably different from their single sorption. Soil-adsorbed TMP was found to effectively inhibit the growth of E. coli at environmentally relevant concentrations in all three soils, and moreover co-presence of SMZ enhanced the antibacterial effects on bacteria both in its dissolved form and soil-adsorbed form. Overall, the results from this study suggest that various soil-adsorbed antibiotic residues could play a joint influencing role in soil bacterial community activity.
甲氧苄啶（TMP）和磺胺嘧啶（SMZ）是两种经常联合使用的抗生素。我们研究了 TMP 和 SMZ 在三种代表性土壤中单独作为单溶质和作为共溶质时的吸附和解吸行为，并评估了土壤吸附抗生素对参考菌株大肠杆菌 ATCC 25922 的联合抗菌活性。比较吸附试验表明，TMP 和 SMZ 的共溶质吸附与它们的单溶质吸附没有显著差异。在所有三种土壤中，土壤吸附的 TMP 被发现以环境相关浓度有效地抑制大肠杆菌的生长，而且 SMZ 的共存增强了其溶解形式和土壤吸附形式的抗生素对细菌的抗菌作用。总的来说，这项研究的结果表明，各种土壤吸附的抗生素残留可能会对土壤细菌群落的活性产生联合影响。
