Takahashi K, Kimura Y, Naito M, Yoshimura T, Uchida H, Araki S
Second Department of Pathology, Kumamoto University Medical School, Japan.
Pathol Res Pract. 1989 May;184(5):498-506. doi: 10.1016/S0344-0338(89)80142-6.
A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.
报告了1例出现类白血病反应的炎性纤维组织细胞瘤。10年前在右肩胛区出现了一个肿瘤，伴有发热和白细胞增多症复发两次，最终出现类白血病反应。除了具有恶性纤维组织细胞瘤典型的组织病理学特征外，该肿瘤还显示出嗜中性白细胞的显著弥漫性浸润。骨髓穿刺液的血液学检查显示骨髓增生。细菌学检查未在肿瘤组织中发现致病微生物。从肿瘤提取物中证实了嗜中性白细胞的趋化活性，将该提取物皮下注射到大鼠体内可诱导动物骨髓中的骨髓增生以及肝脏和脾脏中的嗜中性粒细胞浸润。这些结果提示该病例有可能是产生集落刺激因子的肿瘤。
