2型糖尿病中的瞬目反射

Blink reflex in type 2 diabetes mellitus.

作者信息

Elkholy Saly H, Hosny Hanan M, Shalaby Nevein M, El-Hadidy Reem A, Abd El-Rahim Noha T, Mohamed Manal M

机构信息

*Department of Clinical Neurophysiology, Cairo University, Giza, Egypt; †Department of Clinical Neurophysiology, Beni Suef University, Beni Suef, Egypt; and Departments of ‡Neurology and §Internal Medicine, Cairo University, Giza, Egypt.

出版信息

J Clin Neurophysiol. 2014 Dec;31(6):552-5. doi: 10.1097/WNP.0000000000000103.

DOI:10.1097/WNP.0000000000000103

PMID:25462142

Abstract

PURPOSE

An evaluation of the extent of damage of the central nervous system in diabetes mellitus is of high value in current research. Electrophysiological abnormalities are frequently present in asymptomatic patients with diabetes mellitus. Diabetic cranial neuropathy is one of the complications of the disease. Blink reflex is used to diagnose subclinical cranial neuropathy. The objective is to test the utility of blink reflex in detecting subclinical cranial nerve involvement in patients with type 2 diabetes mellitus.

METHODS

Forty patients with type 2 diabetes mellitus, aged from 30 to 60 years examined clinically and neurologically. Blink reflex and nerve conduction studies for the upper and lower limbs were performed and compared with 20 matched normal controls.

RESULTS

Diabetic patients with peripheral neuropathy showed significant prolonged distal latency and reduced amplitudes of the R2C response compared with the control, patients without peripheral neuropathy showed insignificant changes. Alteration of R2 correlated with the type of treatment and the duration of the disease. In patients without peripheral neuropathy, ulnar sensory distal latencies showed significant positive correlation with R2I latency, whereas its Conduction Velocity (CV) showed significant positive correlation with R2C amplitudes and negative correlation with R2C latency.

CONCLUSIONS

R2C is the most sensitive parameter in the blink reflex, which can help in the diagnosis of subclinical diabetic cranial neuropathy.

摘要

目的

评估糖尿病患者中枢神经系统的损伤程度在当前研究中具有很高的价值。电生理异常在无症状糖尿病患者中经常出现。糖尿病性颅神经病变是该疾病的并发症之一。眨眼反射用于诊断亚临床颅神经病变。目的是测试眨眼反射在检测2型糖尿病患者亚临床颅神经受累情况中的效用。

方法

对40例年龄在30至60岁之间的2型糖尿病患者进行临床和神经学检查。进行眨眼反射以及上肢和下肢的神经传导研究，并与20名匹配的正常对照进行比较。

结果

与对照组相比，患有周围神经病变的糖尿病患者R2C反应的远端潜伏期显著延长且波幅降低，无周围神经病变的患者变化不明显。R2的改变与治疗类型和疾病持续时间相关。在无周围神经病变的患者中，尺神经感觉远端潜伏期与R2I潜伏期呈显著正相关，而其传导速度（CV）与R2C波幅呈显著正相关，与R2C潜伏期呈负相关。