Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
Department of Neuroelectrophysiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China.
J Diabetes Res. 2021 Mar 12;2021:2473193. doi: 10.1155/2021/2473193. eCollection 2021.
Blink reflex provides an objective assessment of the cranial and central nervous systems. However, the relationships between body mass index, dizziness, and BR have not been explored in patients with type 2 diabetes mellitus (T2DM). Moreover, R2 duration, one of the parameters of the blink reflex, has not been studied to date. In the present study, we aimed to investigate the characteristics and influencing factors of blink reflex in patients with T2DM. We included 45 healthy subjects and 105 hospitalized patients with T2DM. The relationships between these parameters and sex, age, body mass index, duration of T2DM, hemoglobin A1c, distal symmetrical polyneuropathy (DSPN), and dizziness symptoms were analyzed. The results showed that blink reflex latencies (including R1, ipsilateral R2, and contralateral R2 latency) were negatively associated with body mass index but were positively correlated with the duration of T2DM. There were no correlations between blink reflex parameters and sex, age, and hemoglobin A1c. Patients with DSPN had longer blink reflex latencies and shorter R2 durations than those without DSPN. Patients with dizziness had longer latencies (including R1, ipsilateral R2, and contralateral R2 latencies) and shorter R2 durations (including ipsilateral R2 and contralateral R2 durations) than those without dizziness. R2 duration was also a predictive factor for blink reflex abnormality. R2 latency was the most sensitive factor and the optimal predictor of dizziness. These results demonstrate that patients with T2DM with low body mass index, longer duration of T2DM, DSPN, and dizziness-related symptoms had more abnormal blink reflex parameters, indicating more serious injuries to the cranial nerves or the central nervous system.
眨眼反射提供了对颅神经和中枢神经系统的客观评估。然而，尚未研究 2 型糖尿病（T2DM）患者的体重指数、头晕与 BR 之间的关系。此外，眨眼反射的一个参数 R2 持续时间迄今尚未研究过。在本研究中，我们旨在研究 T2DM 患者眨眼反射的特征和影响因素。我们纳入了 45 名健康受试者和 105 名住院 T2DM 患者。分析了这些参数与性别、年龄、体重指数、T2DM 病程、糖化血红蛋白、远端对称性多发性神经病（DSPN）和头晕症状之间的关系。结果表明，眨眼反射潜伏期（包括 R1、同侧 R2 和对侧 R2 潜伏期）与体重指数呈负相关，但与 T2DM 病程呈正相关。眨眼反射参数与性别、年龄和糖化血红蛋白无关。有 DSPN 的患者的眨眼反射潜伏期较长，R2 持续时间较短。有头晕症状的患者的潜伏期（包括 R1、同侧 R2 和对侧 R2 潜伏期）较长，R2 持续时间（包括同侧 R2 和对侧 R2 持续时间）较短。R2 持续时间也是眨眼反射异常的预测因素。R2 潜伏期是最敏感的因素，也是头晕的最佳预测因素。这些结果表明，体重指数低、T2DM 病程长、有 DSPN 和头晕相关症状的 T2DM 患者的眨眼反射参数异常更多，表明颅神经或中枢神经系统损伤更严重。
