Uldry P A, Regli F
Schweiz Rundsch Med Prax. 1989 Jun 6;78(23):667-70.
Peripheral neuropathy is a common manifestation of chemotherapeutic agents. Most drugs produce a distal axonal degeneration and long axons are predominantly affected, giving a clinical picture characterized by a symmetrical sensory neuropathy. The toxicity of therapeutic agents to the peripheral nervous system particularly includes those used in cancer-chemotherapy (cisplatin, vinca alkaloids), but antimicrobial agents such as isoniazide or nitrofurantoin and vitamin abuse (pyridoxine) are also discussed.
周围神经病变是化疗药物的常见表现。大多数药物会导致远端轴索性变性，长轴突主要受累，临床表现为对称性感觉神经病变。治疗药物对周围神经系统的毒性尤其包括用于癌症化疗的药物（顺铂、长春花生物碱），但也会讨论如异烟肼或呋喃妥因等抗菌剂以及维生素滥用（如吡哆醇）的情况。
