催乳素：炎症和自身免疫病理的多功能调节剂。
Prolactin: a versatile regulator of inflammation and autoimmune pathology.
机构信息
Neuroimmunology and Neuromuscular Disorder Unit, Neurological Institute Foundation IRCCS C. Besta, Milan 20133, Italy.
INSERM U693, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre 94276, France.
出版信息
Autoimmun Rev. 2015 Mar;14(3):223-30. doi: 10.1016/j.autrev.2014.11.005. Epub 2014 Nov 14.
Prolactin (PRL) has long been proposed as an immune-stimulating and detrimental factor in autoimmune disorders. However, recent findings have challenged this common view, showing that PRL does not play a crucial role in the development of experimental autoimmune encephalomyelitis, animal model for multiple sclerosis (MS), and even protects against adjuvant-induced model of rheumatoid arthritis (RA). In this review we provide a critical overview of data supporting a role for PRL in the regulation of immune responses. In addition, we focus on studies exploring the involvement of PRL in autoimmune diseases, such as systemic lupus erythematosus, MS and RA, in light of the recently-outlined regenerative properties of this hormone.
催乳素（PRL）长期以来一直被认为是自身免疫性疾病中的一种免疫刺激和有害因素。然而，最近的研究结果挑战了这一普遍观点，表明 PRL 在实验性自身免疫性脑脊髓炎（多发性硬化症的动物模型）的发展中不起关键作用，甚至可以预防佐剂诱导的类风湿关节炎（RA）模型。在这篇综述中，我们批判性地概述了支持 PRL 在免疫反应调节中的作用的数据。此外，我们还重点研究了 PRL 在系统性红斑狼疮、多发性硬化症和类风湿关节炎等自身免疫性疾病中的作用，同时考虑到这种激素的最近描述的再生特性。
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