测量冠状动脉钙化：血清维生素D与之有关吗？
Measuring coronary artery calcification: is serum vitamin D relevant?
作者信息
Malik Rehan, Aneni Ehimen C, Roberson Lara, Ogunmoroti Oluseye, Ali Shozab S, Shaharyar Sameer, Younus Adnan, Jamal Omar, Aziz Muhammad A, Martin Seth S, Blaha Michael J, Feldman Theodore, Agatston Arthur S, Veledar Emir, Nasir Khurram
机构信息
Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA.
Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL, USA.
出版信息
Atherosclerosis. 2014 Dec;237(2):734-8. doi: 10.1016/j.atherosclerosis.2014.10.087. Epub 2014 Oct 28.
OBJECTIVES
To synthesize evidence of the association between low vitamin D levels and subclinical coronary atherosclerosis measured by coronary artery calcium (CAC).
METHODS
A systematic MEDLINE search was conducted for relevant published literature. Ten studies (7 cross-sectional, 3 longitudinal) met the inclusion criteria.
RESULTS
Three of 6 studies showed association with CAC prevalence (CAC >0 or >10). Four of 8 studies found an association with CAC severity. One of two studies reported an association with CAC progression, while the only study that assessed CAC incidence did not find a significant relationship. Several of the studies had small sample sizes, many did not adjust for confounders and the cut-off for low vitamin D was inconsistent.
CONCLUSION
There is insufficient evidence to support a consistent association between low vitamin D levels and CAC. Further high-quality studies are needed to examine serum 25-OH vitamin D in relation to subclinical coronary atherosclerosis.
目的
综合有关低维生素D水平与通过冠状动脉钙化（CAC）测量的亚临床冠状动脉粥样硬化之间关联的证据。
方法
对MEDLINE进行系统检索以查找相关已发表文献。十项研究（7项横断面研究，3项纵向研究）符合纳入标准。
结果
6项研究中的3项显示与CAC患病率（CAC>0或>10）有关联。8项研究中的4项发现与CAC严重程度有关联。两项研究中的一项报告与CAC进展有关联，而唯一评估CAC发病率的研究未发现显著关系。其中几项研究样本量较小，许多未对混杂因素进行校正，且低维生素D的临界值不一致。
结论
没有足够的证据支持低维生素D水平与CAC之间存在一致的关联。需要进一步开展高质量研究来检测血清25-羟基维生素D与亚临床冠状动脉粥样硬化的关系。
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