CNR - ISTM, Nanotechnology Lab., Via G. Fantoli 16/15, 20138 Milan, Italy; Department of Chemistry, University of Milan, Via C. Golgi 19, 20133 Milan, Italy.
CNR - ISTM, Nanotechnology Lab., Via G. Fantoli 16/15, 20138 Milan, Italy.
J Colloid Interface Sci. 2015 Feb 1;439:28-33. doi: 10.1016/j.jcis.2014.10.025. Epub 2014 Oct 23.
A preparative protocol to synthesize large quantities of size-controlled gold nanoparticles (Au NPs), stabilized by CH3O-PEG5000-SH (PEG-SH) in aqueous medium, is reported. The combination of metal vapor synthesis (MVS) technique with digestive ripening process allowed to obtain PEGylated Au NPs with mean core particle size of 3.8nm and hydrodynamic diameters centered at 8.0nm which were effectively used as computed tomography (CT) contrast agents for in vivo experiments on mice. The surface functionalization together with the small hydrodynamic diameters of the engineered Au nanoparticles permitted their efficient renal clearance, still retaining a prolonged blood circulation and a stealth capability.
本文报道了一种在水相介质中用 CH3O-PEG5000-SH（PEG-SH）稳定的大量、尺寸可控的金纳米粒子（Au NPs）的制备方案。金属蒸汽合成（MVS）技术与消化陈化过程的结合，可得到平均核粒子尺寸为 3.8nm，水动力直径集中在 8.0nm 的聚乙二醇化 Au NPs，这些 NPs 可有效用作小鼠体内实验的计算机断层扫描（CT）造影剂。表面功能化和工程 Au 纳米粒子的小水动力直径使其能够有效被肾脏清除，同时仍保持较长的血液循环和隐身能力。
