[The influence of dynorphin A (1-13) on lipid peroxidation and antioxidant enzymes activity in the immobilization stress of different duration].

It was revealed in experiments on rats, that selective agonist of opioid kappa-receptors dynorphin A (1-13) has expressed antioxidant action in immobilization stress of different duration. It manifests itself with the decreases of the content of lipid peroxidation metabolites in liver tissue. It was shown, that the effect of this peptide on the activity of antioxidant enzymes superoxiddismutase and catalase depends on the stress duration. The stimulatory influence of peptide on catalase activity was shown in the rats after 3-hours immobilization, but the analogue effect of dynorphin was less in the animals after 6-hours or 12-hours stress. The stimulatory action of dynorphin A (1-13) on the superoxiddismutase activity was established in the rats after 6-hours or 12-hours immobilization within the experiment period, but peptide had no effect in the rats after 3-hours stress.