Ershov F I, Tazulakhova E B
Antibiot Khimioter. 1989 Apr;34(4):270-6.
Data on the immunomodulating activity of interferon inductors are presented. It was revealed that the inductors increased the animal vaccinal response. Schemes for combined use of the interferon inductors and immunomodulators were developed. The immunomodulators were shown to increase the host interferon response evident from synergistic increasing of the interferon titers or prolongation of interferon circulation in blood of the animals. The efficiency of the schemes for combined use of the interferon inductors and immunomodulators was obvious from stimulation of the antibody production. As a result the time of the antibody circulation in blood increased. The effect of the combined use of the immunomodulators and interferon inductors was studied. The combined use of the preparations significantly increased the average life-span of the animals and the rate of their survival.
本文展示了关于干扰素诱导剂免疫调节活性的数据。研究发现,这些诱导剂可增强动物的疫苗接种反应。同时还制定了干扰素诱导剂与免疫调节剂联合使用的方案。结果表明,免疫调节剂可增强宿主的干扰素反应,这从动物血液中干扰素滴度的协同增加或干扰素循环时间的延长中得以体现。干扰素诱导剂与免疫调节剂联合使用方案的有效性在抗体产生的刺激作用中显而易见。因此,抗体在血液中的循环时间增加。对免疫调节剂与干扰素诱导剂联合使用的效果进行了研究。制剂的联合使用显著提高了动物的平均寿命及其存活率。