Souza Paulo Victor Sgobbi de, Pinto Wladimir Bocca Vieira de Rezende, Oliveira Acary Souza Bulle
Divisão de Doencas Neuromusculares, Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2014 Dec;72(12):966-71. doi: 10.1590/0004-282X20140160. Epub 2014 Dec 2.
During recent years, an increasing number of neuromuscular diseases have been recognized either to be caused primarily by autoimmune mechanisms, or to have important autoimmune components. The involved pathophysiological mechanisms and clinical manifestations have been better recognized and many of these disorders are potentially treatable by immunosuppression or by immunomodulation with intravenous immunoglobulin (IVIg). IVIg has been tried in a variety of immune-mediated neurological diseases, being target of widespread use in central and peripheral nervous systems diseases.
To give an overview of the main topics regarding the mechanism of action and different therapeutic uses of IVIg in neurological practice, mainly in neuromuscular diseases.
近年来，越来越多的神经肌肉疾病被认为主要由自身免疫机制引起，或具有重要的自身免疫成分。所涉及的病理生理机制和临床表现已得到更好的认识，其中许多疾病可通过免疫抑制或静脉注射免疫球蛋白（IVIg）进行免疫调节来治疗。IVIg已在多种免疫介导的神经系统疾病中进行了试验，广泛应用于中枢和周围神经系统疾病。
概述IVIg在神经科实践中的作用机制和不同治疗用途的主要内容，主要是在神经肌肉疾病方面。
