体温过低增强了MK-801对幼鼠缺氧缺血性脑损伤的保护作用。

Hypothermia enhances protective effect of MK-801 against hypoxic/ischemic brain damage in infant rats.

作者信息

Ikonomidou C, Mosinger J L, Olney J W

机构信息

Department of Psychiatry, Washington University Medical School, St. Louis, MO 63110.

出版信息

Brain Res. 1989 May 15;487(1):184-7. doi: 10.1016/0006-8993(89)90956-6.

DOI:10.1016/0006-8993(89)90956-6

PMID:2546648

Abstract

Accumulating evidence suggests that the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor may play an important role in hypoxic/ischemic (H/I) brain damage. Accordingly, it has been shown that the NMDA antagonist, MK-801, partially protects the infant rat brain against H/I damage. Here we show that reducing the body temperature of the infant rat also confers partial protection against H/I brain damage and that mild hypothermia plus MK-801 treatment provides total protection against such damage. Relevance of these findings to the prevention of perinatal brain damage in humans is discussed.

摘要

越来越多的证据表明，谷氨酸受体的N-甲基-D-天冬氨酸（NMDA）亚型可能在缺氧/缺血性（H/I）脑损伤中起重要作用。因此，已有研究表明，NMDA拮抗剂MK-801可部分保护幼鼠大脑免受H/I损伤。在此我们表明，降低幼鼠体温也可部分保护其免受H/I脑损伤，且轻度低温加MK-801治疗可完全保护其免受此类损伤。本文还讨论了这些发现与预防人类围产期脑损伤的相关性。