发展中国家重症急性肾损伤儿童的临床特征与住院结局
Clinical profile and hospital outcome of children with severe acute kidney injury in a developing country.
作者信息
Esezobor Christopher Imokhuede, Ladapo Taiwo Augustina, Lesi Foluso Ebun
机构信息
Department of Paediatrics, College of Medicine, University of Lagos, Idi-Araba, Mushin, Lagos State, Nigeria Department of Paediatrics, Lagos University Teaching Hospital, Idi-Araba, 101014 Mushin, Lagos State, Nigeria
Department of Paediatrics, College of Medicine, University of Lagos, Idi-Araba, Mushin, Lagos State, Nigeria Department of Paediatrics, Lagos University Teaching Hospital, Idi-Araba, 101014 Mushin, Lagos State, Nigeria.
出版信息
J Trop Pediatr. 2015 Feb;61(1):54-60. doi: 10.1093/tropej/fmu066. Epub 2014 Dec 1.
INTRODUCTION
In resource-constraint regions of the world, the spectrum of childhood diseases is changing, creating a need to clearly define the epidemiology of severe acute kidney injury (AKI).
METHODS
Medical records of children aged between 1 month and 17 years with stage 3 AKI in a tertiary hospital were reviewed.
RESULTS
Ninety-one children, comprising 63 (69.2%) males and 26 (28.6%) infants, were studied. Majority (75.8%) had stage 3 AKI at the point of hospitalization. Sepsis (41.8%), primary kidney diseases (PKD; 29.7%) and malaria (13.2%) were the most common causes of stage 3 AKI. Twenty-eight (30.8%) children died. Mortality was highest in those with sepsis, less than 5 years old and needing dialysis.
CONCLUSION
Sepsis, PKD and malaria were the most common causes of severe AKI. A third of children with severe AKI died. Mortality was highest in those less than 5 years old, with sepsis and needing dialysis.
引言
在世界资源受限地区，儿童疾病谱正在发生变化，因此需要明确界定重症急性肾损伤（AKI）的流行病学特征。
方法
回顾了一家三级医院中1个月至17岁患有3期AKI儿童的病历。
结果
共研究了91名儿童，其中包括63名（69.2%）男性和26名（28.6%）婴儿。大多数（75.8%）在住院时即处于3期AKI。脓毒症（41.8%）、原发性肾脏疾病（PKD；29.7%）和疟疾（13.2%）是3期AKI最常见的病因。28名（30.8%）儿童死亡。脓毒症患儿、年龄小于5岁且需要透析的患儿死亡率最高。
结论
脓毒症、PKD和疟疾是重症AKI最常见的病因。三分之一的重症AKI儿童死亡。年龄小于5岁、患有脓毒症且需要透析的患儿死亡率最高。
Zotero 插件