Division of Endocrinology, Indiana University School of Medicine, Indianapolis, IN; Endocrinology Section, Roudebush Veterans Affairs Medical Center, Indianapolis, IN.
Division of Endocrinology, Indiana University School of Medicine, Indianapolis, IN.
Trends Cardiovasc Med. 2015 Apr;25(3):250-7. doi: 10.1016/j.tcm.2014.10.014. Epub 2014 Oct 28.
Endogenous testosterone levels are inversely associated with cardiovascular risk in older men and men with cardiovascular disease. Current data on cardiovascular outcomes of testosterone therapy include only observational studies and adverse event monitoring in short-term trials that were not designed to measure cardiovascular outcomes. These studies have yielded conflicting results, and some have raised concerns that testosterone therapy may increase cardiovascular risk. A well-designed, adequately powered, prospective trial will ultimately be required to clarify whether testosterone therapy impacts cardiovascular outcomes. This review describes the findings and limitations of recent studies of cardiovascular risk in older men on testosterone therapy and discusses some of the mechanisms through which testosterone may modify cardiovascular risk.
内源性睾丸激素水平与老年男性和心血管疾病男性的心血管风险呈负相关。目前关于睾丸激素治疗对心血管结局的影响的数据仅包括观察性研究和短期试验中的不良事件监测，这些研究并非专门用于测量心血管结局。这些研究得出了相互矛盾的结果，一些研究还引起了人们的担忧，即睾丸激素治疗可能会增加心血管风险。最终需要进行一项设计良好、充分有力、前瞻性的试验，以明确睾丸激素治疗是否会影响心血管结局。本综述描述了近期关于老年男性接受睾丸激素治疗的心血管风险的研究结果和局限性，并讨论了睾丸激素可能影响心血管风险的一些机制。
