低睾酮和雌激素水平对男性进展性冠状动脉疾病的影响。
The Effect of Low Testosterone and Estrogen Levels on Progressive Coronary Artery Disease in Men.
作者信息
Bajelan Mansoureh, Etehad Roodi Negar, Hasanzadeh Daloee Mahdy, Farhangnia Mansoureh, Samadi Kuchaksaraei Ali
机构信息
Cellular and Molecular Research Centre, Iran University of Medical Science, Tehran, Iran.
Cardiovascular Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Rep Biochem Mol Biol. 2019 Jul;8(2):168-171.
BACKGROUND
Age-related morbidity and mortality rates from coronary heart disease (CHD) are higher in men than in women. Abnormal androgen levels cause a variety of abnormal symptoms in men. Testosterone and estrogen are the main sex hormone in men and women, respectively, and studies have shown that they have important roles in cardiovascular health and disease.
METHODS
We measured testosterone and estrogen in 102 men with coronary heart disease and 45 controls. Blood samples were collected from subjects and plasma testosterone and estrogen were measured by ELISA.
RESULTS
Men with coronary heart disease had less testosterone (OD Ratio: 0.782) and estrogen (OD Ratio: 0.955) than controls.
CONCLUSION
Low testosterone and estrogen levels correlate with coronary artery disease.
背景
冠心病（CHD）的年龄相关发病率和死亡率男性高于女性。雄激素水平异常会在男性身上引发多种异常症状。睾酮和雌激素分别是男性和女性的主要性激素，研究表明它们在心血管健康与疾病中发挥着重要作用。
方法
我们对102名冠心病男性患者和45名对照者的睾酮和雌激素进行了测量。采集受试者的血样，采用酶联免疫吸附测定法（ELISA）检测血浆睾酮和雌激素水平。
结果
冠心病男性患者的睾酮（光密度比值：0.782）和雌激素（光密度比值：0.955）水平低于对照者。
结论
低睾酮和雌激素水平与冠状动脉疾病相关。
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