Khodosova I A, Zakharova N V
Eksp Onkol. 1989;11(3):3-9.
A review of recent papers dealing with the role of protein kinase C (PK C) in regulation of normal and tumour cell proliferation contains the data on the interaction of PK C with the tumour promoters and oncoproteins as well as the data which characterize changes of the PK C activity in tumour cells and during carcinogenesis. Probable mechanisms of the PK C influence on the functioning of the growth factors receptors are discussed. It is proposed that one of the PK C functions which is substantial for induction of the mitogenic signal is the polyamine synthesis stimulation. Participation of PK C in the tumour promotion may play a key role in multistep processes of the carcinogenesis.
一篇关于近期探讨蛋白激酶C（PKC）在正常细胞和肿瘤细胞增殖调控中作用的论文综述，包含了PKC与肿瘤启动子及癌蛋白相互作用的数据，以及表征肿瘤细胞和致癌过程中PKC活性变化的数据。文中讨论了PKC影响生长因子受体功能的可能机制。有人提出，PKC对促有丝分裂信号诱导起重要作用的功能之一是刺激多胺合成。PKC参与肿瘤促进可能在致癌作用的多步骤过程中起关键作用。
