Delitala G, Tomasi P A, Palermo M, Ross R J, Grossman A, Besser G M
Istituto di Endocrinologia e di Ematologia, Università di Sassari, Italy.
J Clin Endocrinol Metab. 1989 Aug;69(2):356-8. doi: 10.1210/jcem-69-2-356.
The Met-enkephalin analog DAMME [D-Ala2,MePhe4-Met-enkephalin-(o)-o1, FK 33-824] can stimulate GH secretion in man. In this study we investigated the effects of the guanyl derivative of DAMME (G-DAMME) on the serum GH response to an analog of GHRH in normal men. GHRH-(1-29)NH2 and G-DAMME each induced a rise in serum GH, and the increase was greater when both were given together. Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that the enhancing effect of G-DAMME on GHRH-induced GH release may be mediated through inhibition of somatostatin release.
甲硫氨酸脑啡肽类似物DAMME [D-丙氨酸2，甲基苯丙氨酸4-甲硫氨酸脑啡肽-(o)-o1，FK 33-824] 可刺激人体生长激素（GH）分泌。在本研究中，我们调查了DAMME的鸟苷衍生物（G-DAMME）对正常男性血清GH对生长激素释放激素（GHRH）类似物反应的影响。GHRH-(1-29)NH2和G-DAMME均可诱导血清GH升高，二者同时给予时升高幅度更大。由于所使用的GHRH-(1-29)NH2剂量（100微克）是最大刺激剂量，这些结果表明，G-DAMME对GHRH诱导的GH释放的增强作用可能是通过抑制生长抑素释放来介导的。
