Nar Gökay, İnci Sinan, Aksan Gökhan, Soylu Korhan, Demirelli Selami, Nar Rukiye
Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey.
Department of Cardiology, Gazi State Hospital, Samsun, Turkey.
Echocardiography. 2015 Sep;32(9):1359-66. doi: 10.1111/echo.12855. Epub 2014 Dec 3.
This study aims to evaluate the relationship between atrial electromechanical delay (AEMD) times and CHA2DS2-VASc scores in patients diagnosed with paroxysmal atrial fibrillation (PAF).
The study included a total of 74 patients, 34 of whom were diagnosed with PAF and 40 were included in the control group. The CHA2DS2-VASc score was calculated for each patient. Additionally, blood samples were taken from all patients and transthoracic echocardiographic measurements were made. Left atrial mechanical functions and AEMD were calculated.
Mean CHA2DS2-VASc score measured was 2.24 ± 1.53 in PAF group. There was no significant difference between the groups when the patients were evaluated for baseline characteristics and laboratory parameters (P > 0.05) The echocardiographic evaluation of LA mechanical functions showed that only LA minimum volume (19 ± 6.4 vs. 16.7 ± 4.6, P = 0.02) and LA presystolic volume (28.9 ± 7 vs. 25.1 ± 5.7, P = 0.01) were higher in the PAF group. When AEMD was compared between the groups; lateral PA, septal PA, tricuspid PA, Interatrial EMD, and intraatrial EMD were significantly extended compared to control group (P < 0.001) CHA2DS2-VASc score was correlated with Lateral atrial PA (P < 0.001, r = 0.524), Septal atrial PA (P < 0.001, r = 0.45), Interatrial EMD (P < 0.001, r = 0.54), and intraatrial EMD (P < 0.001, r = 0.51) times.
The present study shows that AEMD times increase in patients with PAF compared to the control group. Furthermore, this study revealed a correlation between AEMD times and CHA2DS2-VASc score, as well showed that extended AEMD time may be associated with thromboembolism risk.
本研究旨在评估阵发性心房颤动（PAF）患者的心房机电延迟（AEMD）时间与CHA2DS2-VASc评分之间的关系。
该研究共纳入74例患者，其中34例被诊断为PAF，40例纳入对照组。计算每位患者的CHA2DS2-VASc评分。此外，采集所有患者的血样并进行经胸超声心动图测量。计算左心房机械功能和AEMD。
PAF组测得的平均CHA2DS2-VASc评分为2.24±1.53。在评估患者的基线特征和实验室参数时，两组之间无显著差异（P>0.05）。左心房机械功能的超声心动图评估显示，仅PAF组的左心房最小容积（19±6.4对16.7±4.6，P=0.02）和左心房收缩前容积（28.9±7对25.1±5.7，P=0.01）较高。比较两组之间的AEMD时；与对照组相比，外侧PA、间隔PA、三尖瓣PA、房间隔EMD和房内EMD显著延长（P<0.001）。CHA2DS2-VASc评分与外侧心房PA（P<0.001，r=0.524）、间隔心房PA（P<0.001，r=0.45）、房间隔EMD（P<0.001，r=0.54）和房内EMD（P<0.001，r=0.51）时间相关。
本研究表明，与对照组相比，PAF患者的AEMD时间增加。此外，本研究揭示了AEMD时间与CHA2DS2-VASc评分之间的相关性，还表明AEMD时间延长可能与血栓栓塞风险相关。
