解析脂质：脂氧素调节胆固醇逆转运。

Resolving lipids: lipoxins regulate reverse cholesterol transport.

机构信息

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell Metab. 2014 Dec 2;20(6):935-7. doi: 10.1016/j.cmet.2014.11.012.

DOI:10.1016/j.cmet.2014.11.012

PMID:25470544

Abstract

Disruptions in cholesterol homeostasis contribute to cardiovascular disease (CVD). In a recent issue of Cell Metabolism, Demetz et al. (2014) report that endogenous lipoxygenase-mediated metabolism of another lipid, arachidonic acid, produces lipoxins that regulate reverse cholesterol transport. These results suggest that lipoxins may represent a novel class of therapeutics for CVD.

摘要

胆固醇稳态失衡会导致心血管疾病（CVD）。在最近一期的《细胞代谢》杂志上，Demetz 等人（2014）报告称，内源性脂氧合酶介导的另一种脂质——花生四烯酸的代谢产生了脂氧素，调节胆固醇逆向转运。这些结果表明，脂氧素可能代表一类治疗 CVD 的新型药物。