Department of Internal Medicine II, Medical University Innsbruck, Innsbruck 6020, Austria.
Int J Mol Sci. 2018 Oct 23;19(11):3285. doi: 10.3390/ijms19113285.
Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.
脂质和免疫途径在代谢和心血管疾病的病理生理学中起着至关重要的作用。花生四烯酸 (AA) 及其衍生物将营养代谢与免疫和炎症联系起来，因此在肥胖症、糖尿病、非酒精性脂肪肝病和心血管疾病等常见疾病的发生和发展中起着关键作用。本文概述了 AA 在人类健康、组织稳态和免疫中的代谢作用，并探讨了 AA 代谢组在多种病理生理条件和疾病中的作用。
