代谢综合征诊断的最佳生物标志物是什么？
What is the best biomarker for metabolic syndrome diagnosis?
作者信息
Falahi Ebrahim, Khalkhali Rad Amir Hossein, Roosta Sajjad
机构信息
Nutrition Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Nutrition, Faculty of Health & Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
出版信息
Diabetes Metab Syndr. 2015 Oct-Dec;9(4):366-72. doi: 10.1016/j.dsx.2013.06.014. Epub 2013 Jul 31.
AIMS
There are three definitions belong to metabolic syndrome (MetS). These definitions have some differences that make some problem for MetS diagnosis criteria. So a new diagnosis marker can help to MetS diagnosis. The aim of this study was the assess of serum levels of leptin, total adiponectin, high molecular weight (HMW) adiponectin, and their ratio with MetS.
MATERIALS AND METHODS
We searched Science direct, Pubmed, and Google Scholar for related articles in English. Review studies excluded.
RESULTS
Of 1827 articles found, 16 articles met our inclusion criteria. leptin is higher in MetS group but adiponectin is lower (<4 μg/ml) and it shows the paradoxical effect of them in MetS. Higher L/A ratio is a better biomarker for MetS diagnosis criteria than leptin and adiponectin separately. HMW adiponectin (<2.5 μg/ml) can be the most reliable biomarker for MetS diagnosis criteria.
CONCLUSION
Our systematic review showed that HMW adiponectin and Leptin to adiponectin ratio should be the best biomarkers for MetS.
目的
代谢综合征（MetS）有三种定义。这些定义存在一些差异，给MetS的诊断标准带来了一些问题。因此，一种新的诊断标志物有助于MetS的诊断。本研究的目的是评估瘦素、总脂联素、高分子量（HMW）脂联素的血清水平及其与MetS的关系。
材料与方法
我们在科学Direct、PubMed和谷歌学术上搜索英文相关文章。排除综述研究。
结果
在找到的1827篇文章中，16篇符合我们的纳入标准。MetS组中瘦素水平较高，但脂联素水平较低（<4μg/ml），这显示了它们在MetS中的矛盾作用。较高的L/A比值比单独的瘦素和脂联素是更好的MetS诊断标准生物标志物。HMW脂联素（<2.5μg/ml）可能是MetS诊断标准中最可靠的生物标志物。
结论
我们的系统评价表明，HMW脂联素和瘦素与脂联素的比值应该是MetS的最佳生物标志物。
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