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[剧烈增强的运动活动对大鼠心脏泵血能力的影响及其调节机制]

[Effect of the sharply strengthened motor activity on heart pumping ability of rats and mechanisms of its regulation].

作者信息

Nikitin A S, Abzalov R A, Abzalov N I, Vafina E Z

出版信息

Ross Fiziol Zh Im I M Sechenova. 2013 Aug;99(8):937-44.

Abstract

The indicators of heart pumping ability of rats at a muscular loading of the maximum power and also in the conditions of transition from sharply strengthened motor activity regime on a strengthened motor activity regime at adrenergic influence stimulation and blockade were investigated. At rats of 100-daily age at the strengthened motor activity heart rate is less, and blood stroke volume is more, than in the rats, subject to muscular loading of the maximum power. The adrenergic influence on the heart's pumping ability of sharply strengthened motor activity rats is much more, than of unlimited motor activity rats. At the α1-adrenoreceptors blockade at 100-daily rats the decreasing in intensity of muscular loading causes increased in adrenergic influence on heart pumping ability.

摘要

研究了大鼠在最大功率肌肉负荷下以及在肾上腺素能影响刺激和阻断时,从急剧增强的运动活动状态转变为增强的运动活动状态的条件下心脏泵血能力的指标。在100日龄的大鼠中,与处于最大功率肌肉负荷的大鼠相比,在增强的运动活动状态下心率较低,而每搏输出量较高。肾上腺素能对急剧增强的运动活动大鼠心脏泵血能力的影响比对无限制运动活动大鼠的影响大得多。在100日龄大鼠的α1-肾上腺素能受体阻断时,肌肉负荷强度的降低导致肾上腺素能对心脏泵血能力的影响增加。

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