致癌物预处理及随后的创伤所产生的上皮发育异常。
Epithelial dysplasia produced by carcinogen pretreatment and subsequent wounding.
作者信息
Maeda H, Kameyama Y, Nakane S, Takehana S, Sato E
机构信息
Department of Pathology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
出版信息
Oral Surg Oral Med Oral Pathol. 1989 Jul;68(1):50-6. doi: 10.1016/0030-4220(89)90114-x.
Golden hamsters in which the tongues were pretreated with DMBA for 4 weeks, subsequently excised, and either received no treatment or received additional postexcisional applications of acetone or DMBA for 9 to 13 days exhibited histologic evidence of epithelial dysplasia; these dysplastic lesions stained positive for papillomavirus genus-specific antigens. Conversely, animals in which the tongues received the same pretreatment yet had no excision failed to show any dysplastic changes, even though the tongues received additional applications of DMBA. Furthermore, papillomavirus genus-specific antigens were not demonstrable. The animals in which the tongues received no pretreatment with DMBA for 4 weeks followed by excisional wounding showed normal healing, even though the tongues were post-treated with DMBA. Papillomavirus genus-specific antigens could not be demonstrated in this last group.
将舌头用二甲基苯并蒽（DMBA）预处理4周的金黄仓鼠，随后切除舌头，然后要么不接受任何处理，要么在切除后额外应用丙酮或DMBA 9至13天，这些仓鼠表现出上皮发育异常的组织学证据；这些发育异常的病变对乳头瘤病毒属特异性抗原有阳性染色。相反，那些舌头接受相同预处理但未切除的动物，即使舌头额外应用了DMBA，也未显示出任何发育异常的变化。此外，未检测到乳头瘤病毒属特异性抗原。那些舌头未用DMBA预处理4周而是先进行切除性创伤的动物，即使在切除后用DMBA处理，也显示出正常愈合。在最后一组中未检测到乳头瘤病毒属特异性抗原。
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