肾母细胞瘤及相关综合征。一种统一理论。
Wilms' tumour and related syndromes. A unifying theory.
作者信息
Côté G B
机构信息
Genetics Division, Institute of Child Health, Athens, Greece.
出版信息
Ann Genet. 1989;32(2):69-72.
PMID:2547332
Abstract
The major role of somatic crossing-over in the aetiology of Wilms' tumour and other forms of cancer is emphasized. A model is proposed to show that tumour development is due to a cis-trans disruptive effect of somatic crossing-over on the maintenance of differential parental imprinting.
摘要
着重强调了体细胞交换在肾母细胞瘤及其他癌症病因学中的主要作用。提出了一个模型，以表明肿瘤的发展是由于体细胞交换对维持亲本差异印记产生的顺式-反式破坏效应。
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