血液系统恶性肿瘤中的癌症相关成纤维细胞
Cancer associated fibroblasts in hematological malignancies.
作者信息
Raffaghello Lizzia, Vacca Angelo, Pistoia Vito, Ribatti Domenico
机构信息
Laboratorio di Oncologia, Istituto G. Gaslini, Genova, Italy.
Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy.
出版信息
Oncotarget. 2015 Feb 20;6(5):2589-603. doi: 10.18632/oncotarget.2661.
Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.
肿瘤微环境在癌症的发生和发展中起着重要作用。在血液系统恶性肿瘤中，骨髓是肿瘤微环境展现其形态功能特征的典型解剖部位。在构成这种微环境的细胞中，与癌症相关的成纤维细胞（CAFs）在造血系统肿瘤中相比实体癌受到的关注较少。在这篇综述文章中，我们讨论了CAFs在血液系统恶性肿瘤进展中的作用以及从治疗角度对CAFs进行靶向治疗的潜力。
Zotero 插件