Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124 Bari, Italy.
Immunol Lett. 2013 May;152(2):83-8. doi: 10.1016/j.imlet.2013.05.003. Epub 2013 May 15.
Mast cells and macrophages are critical regulators of inflammation and immunological response in the tumor microenvironment. Increased number of mast cells and macrophages have been reported to correlate with poor prognosis in numerous solid and hematological tumors. In contrast to their pro-tumorigenic role, mast cells and macrophages have shown also anti-tumorigenic effect in certain malignancies, for example by supporting cancer rejection. Thus, mast cells and macrophages can exert both detrimental and beneficial effects on tumor progression. Mast cell- and macrophages-derived growth factors able to promote tumor development and angiogenesis include TNF-α, TGF-β1, FGF-2, VEGF, PDGF, IL-8, osteopontin, and NGF. On the contrary, mast cell- and macrophages-produced cytokines that may participate in anti-tumor response include IL-1, IL-2, IL-4, IL-10, and IFN-γ. It is to note that mast cells and macrophages may also show beneficial and detrimental effects in the same cancer depending on the tumor stage.
肥大细胞和巨噬细胞是肿瘤微环境中炎症和免疫反应的关键调节剂。已经报道，在许多实体瘤和血液系统肿瘤中，肥大细胞和巨噬细胞数量的增加与预后不良相关。与它们的促肿瘤作用相反，肥大细胞和巨噬细胞在某些恶性肿瘤中也表现出抗肿瘤作用，例如通过支持癌症排斥。因此，肥大细胞和巨噬细胞可以对肿瘤进展产生既有害又有益的影响。能够促进肿瘤发展和血管生成的肥大细胞和巨噬细胞衍生的生长因子包括 TNF-α、TGF-β1、FGF-2、VEGF、PDGF、IL-8、骨桥蛋白和 NGF。相反，肥大细胞和巨噬细胞产生的可能参与抗肿瘤反应的细胞因子包括 IL-1、IL-2、IL-4、IL-10 和 IFN-γ。需要注意的是，肥大细胞和巨噬细胞在同一癌症中也可能表现出有益和有害的影响，这取决于肿瘤的阶段。
