接头后α2肾上腺素能受体介导人体皮下阻力血管的血管收缩。
Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels.
作者信息
Nielsen H, Thom S M, Hughes A D, Martin G N, Mulvany M J, Sever P S
机构信息
Department of Clinical Pharmacology, Queen Elisabeth The Queen Mother Wing, St. Mary's Hospital, London.
出版信息
Br J Pharmacol. 1989 Jul;97(3):829-34. doi: 10.1111/j.1476-5381.1989.tb12022.x.
Abstract
- In vitro studies have been performed on human medium-sized muscular arteries (internal diameter 1-4 mm) in a classical organ bath and with human subcutaneous resistance arteries (internal diameter 103-626 microns) in a microvascular myograph. 2. Although the medium-sized muscular arteries showed no response to either of the alpha 2-agonists B-HT 933 or UK 14304 in concentrations up to 10 microM, the subcutaneous resistance arteries from all regions examined showed well-pronounced and concentration-dependent responses to B-HT 933, the pD2 (-log EC50) being 5.11 +/- 0.09. 3. In the resistance arteries the alpha 2-antagonist yohimbine caused a parallel shift to the right of the B-HT 933 concentration-response curve; the yohimbine pA2 for the B-HT 933 receptor was 7.86 +/- 0.12. 4. There was an inverse relationship between the maximum response to B-HT 933 and the calibre of the resistance vessels. 5. These results indicate the presence of a postjunctional alpha 2-adrenoceptor in human subcutaneous resistance arteries and not in medium sized muscular arteries.
摘要
- 已在经典器官浴槽中对人中型肌性动脉（内径1 - 4毫米）以及在微血管肌动描记器中对人皮下阻力动脉（内径103 - 626微米）进行了体外研究。2. 尽管中型肌性动脉对浓度高达10微摩尔的两种α2激动剂B - HT 933或UK 14304均无反应，但所有检查区域的皮下阻力动脉对B - HT 933均表现出明显的浓度依赖性反应，pD2（-log EC50）为5.11±0.09。3. 在阻力动脉中，α2拮抗剂育亨宾使B - HT 933浓度 - 反应曲线向右平行移动；育亨宾对B - HT 933受体的pA2为7.86±0.12。4. 对B - HT 933的最大反应与阻力血管的管径之间存在反比关系。5. 这些结果表明人皮下阻力动脉中存在节后α2肾上腺素能受体，而中型肌性动脉中不存在。
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