Teixeira Sara R, Dalto Vitor F, Maranho Daniel A, Zoghbi-Neto Orlando S, Volpon José B, Nogueira-Barbosa Marcello H
Division of Radiology, Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, 3900 Ribeirao Preto, Sao Paulo 14049-090, Brazil.
Division of Pediatric Orthopaedics, Department of Biomechanics, Medicine, and Rehabilitation of the Locomotor System, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, 3900 Ribeirao Preto, Sao Paulo 14049-090, Brazil.
Eur J Radiol. 2015 Feb;84(2):301-6. doi: 10.1016/j.ejrad.2014.11.003. Epub 2014 Nov 14.
To evaluate whether the pubo-femoral distance (PFD) can be used as an accurate screening test to diagnose developmental dysplasia of the hip (DDH) in an at-risk population compared with the Graf method. Second, to determine whether PFD assessment is feasible and reproducible regardless of the observer's experience.
IRB approved this retrospective single-institution study. Written informed consent was waived. Between January 2010 and March 2012, 116 neonates at risk for DDH were included. Infants' hips were distributed into two groups according to recommendation for treatment: non-dysplastic (ND; Graf I/IIA; 211 hips; 69 females/37 males) and dysplastic hip (DH; Graf IIB/IIC/III/D/IV; 21 hips; 8 females/3 males). One resident and one experienced radiologist reviewed ultrasonography images performed in the fourth week. To compare the groups, Student's t and Mann-Whitney tests for normally and non-normally distributed covariates were performed. Accuracy of PFD to diagnose DDH was calculated. Intraclass correlation coefficient (ICC) was calculated to assess inter-observer agreement.
Mean PFDs of ND group were 3.09mm at neutral position and 3.64mm with the hip flexed. Mean PFDs of DH group were 6.29mm and 7.59mm, respectively. Sensitivity, specificity, and accuracy of PFD were 94.4%, 93.4%, and 97.2% (cut-off=4.6mm) at neutral position and 94.4%, 89.0%, and 95.5% (cut-off=4.9mm) with hip flexed. ICCs were 0.852 and 0.864, respectively.
PFD is comparable with Graf method, enabling physicians to differentiate patients who should undergo treatment from those who should not. PFD can be used as a screening tool for diagnosing DDH with high accuracy, even by inexperienced radiologists.
评估耻骨-股骨距离(PFD)与Graf方法相比,能否作为一种准确的筛查试验来诊断高危人群中的发育性髋关节发育不良(DDH)。其次,确定无论观察者的经验如何,PFD评估是否可行且可重复。
机构审查委员会批准了这项回顾性单机构研究。书面知情同意书被豁免。在2010年1月至2012年3月期间,纳入了116名有DDH风险的新生儿。根据治疗建议,将婴儿的髋关节分为两组:非发育不良组(ND;Graf I/IIA;211个髋关节;69名女性/37名男性)和发育不良髋关节组(DH;Graf IIB/IIC/III/D/IV;21个髋关节;8名女性/3名男性)。一名住院医师和一名经验丰富的放射科医生对第四周进行的超声图像进行了评估。为比较两组,对正态分布和非正态分布的协变量分别进行了Student's t检验和Mann-Whitney检验。计算了PFD诊断DDH的准确性。计算组内相关系数(ICC)以评估观察者间的一致性。
ND组中立位时的平均PFD为3.09mm,髋关节屈曲时为3.64mm。DH组的平均PFD分别为6.29mm和7.59mm。中立位时PFD的敏感性、特异性和准确性分别为94.4%、93.4%和97.2%(临界值=4.6mm),髋关节屈曲时分别为94.4%、89.0%和95.5%(临界值=4.9mm)。ICC分别为0.852和0.864。
PFD与Graf方法相当,使医生能够区分哪些患者需要治疗,哪些患者不需要治疗。PFD可作为一种高精度诊断DDH的筛查工具,即使是经验不足的放射科医生也能使用。