Kilic Arman, Sultan Ibrahim S, Arnaoutakis George J, Black James H, Reifsnyder Thomas
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD.
Department of Surgery, Johns Hopkins Bayview Medical Center, Baltimore, MD.
Ann Vasc Surg. 2015 Apr;29(3):526-33.e2. doi: 10.1016/j.avsg.2014.09.031. Epub 2014 Dec 1.
An increasing number of patients undergoing noncardiac surgery have coronary stents. Although guidelines regarding perioperative management of antiplatelet therapies in this patient population exist, practice patterns remain incompletely understood. This study evaluated these practice patterns, with particular attention to differences in management between vascular and nonvascular surgeons.
A link to a 16-question survey was displayed in the American College of Surgeons (ACS) electronic newsletter NewsScope, which is posted on the ACS Web site. Questions were focused on perioperative management of antiplatelets (aspirin, clopidogrel) for bare-metal (BMS; placed within 2 months) and drug-eluting stents (DES; placed within the past year) during low- and high-risk bleeding procedures, assuming a patient with no other confounding medical issues. Primary stratification was by surgeon specialty.
A total of 244 surgical providers responded to the survey, of which 40 (17%) were vascular surgeons. The majority of respondents were attending surgeons in practice for at least 10 years (79%, n = 190). A significantly higher percentage of vascular versus nonvascular surgeons would not stop aspirin preoperatively in low bleeding risk procedures (BMS: 90% vs. 54%, P = 0.001; DES: 88% vs. 58%, P = 0.009). A higher percentage of vascular surgeons would not stop aspirin preoperatively in high bleeding risk procedures as well (BMS: 70% vs. 28%, P < 0.001; DES: 78% vs. 32%, P < 0.001). Most vascular surgeons would not stop clopidogrel in a low-risk BMS patient (53% vs. 21% of nonvascular surgeons, P = 0.001). Similar findings with clopidogrel were observed in low- (would not stop: 65% vascular versus 30% nonvascular, P < 0.001) and high-risk DES patients (would not stop: 30% vascular versus 8% nonvascular, P = 0.001). The same trends were observed in resuming antiplatelets in the postoperative period. The majority of respondents were not familiar with professional guidelines regarding perioperative antiplatelet management (52%, n = 128), with no differences between vascular and nonvascular surgeons (45% vs. 54%, P = 0.30).
This national survey demonstrates significant variation in perioperative antiplatelet management in patients with coronary stents, with marked differences between vascular and nonvascular surgeons. More effective communication of existing guidelines or the development of new specialty-specific professional guidelines appears prudent in reducing this variability in practice.
接受非心脏手术的患者中,植入冠状动脉支架的人数日益增加。尽管针对这一患者群体围手术期抗血小板治疗的管理已有指南,但实际操作模式仍未完全明确。本研究评估了这些实际操作模式,特别关注血管外科医生和非血管外科医生在管理上的差异。
美国外科医师学会(ACS)电子通讯NewsScope(发布于ACS网站)上展示了一份包含16个问题的调查问卷链接。问题聚焦于在低出血风险和高出血风险手术中,针对裸金属支架(BMS;植入时间在2个月内)和药物洗脱支架(DES;植入时间在过去一年)的围手术期抗血小板(阿司匹林、氯吡格雷)管理,假设患者无其他混杂的医疗问题。主要分层依据外科医生的专业。
共有244名外科医疗人员回复了调查,其中40名(17%)为血管外科医生。大多数受访者是从业至少10年的主治医生(79%,n = 190)。在低出血风险手术中,血管外科医生术前不停用阿司匹林的比例显著高于非血管外科医生(BMS:90% 对 54%,P = 0.001;DES:88% 对 58%,P = 0.009)。在高出血风险手术中,血管外科医生术前不停用阿司匹林的比例也更高(BMS:70% 对 28%,P < 0.001;DES:78% 对 32%,P < 0.001)。大多数血管外科医生在低风险BMS患者中不会停用氯吡格雷(53%,而非血管外科医生为21%,P = 0.001)。在低风险DES患者(不会停用:血管外科医生为65%,非血管外科医生为30%,P < 0.001)和高风险DES患者(不会停用:血管外科医生为30%,非血管外科医生为8%,P = 0.001)中,氯吡格雷也有类似发现。术后恢复抗血小板治疗时也观察到相同趋势。大多数受访者不熟悉围手术期抗血小板管理的专业指南(52%,n = 128),血管外科医生和非血管外科医生之间无差异(45% 对 54%,P = 0.30)。
这项全国性调查表明,冠状动脉支架患者围手术期抗血小板管理存在显著差异,血管外科医生和非血管外科医生之间存在明显不同。为减少实际操作中的这种差异,更有效地传达现有指南或制定新的专业特定指南似乎是明智之举。