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达格列净

Dapagliflozin.

作者信息

Cada Dennis J, Levien Terri L, Baker Danial E

机构信息

Founder and Contributing Editor, The Formulary , Washington State University , Spokane, Washington.

Clinical Professor, Drug Information Center, Washington State University , Spokane, Washington.

出版信息

Hosp Pharm. 2014 Jul;49(7):647-62. doi: 10.1310/hpj4907-647.

DOI:10.1310/hpj4907-647
PMID:25477585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4252236/
Abstract

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. A drug class review is now published monthly with The Formulary Monograph Service. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, call The Formulary at 800-322-4349. The July 2014 monograph topics are albiglutide, ramucirumab, short ragweed pollen allergen extract, timothy grass pollen allergen extract, and isavuconazole. The DUE/MUE is on albiglutide.

摘要

《处方集专论服务》的订阅者每月会收到5至6篇关于新发布或处于3期临床试验后期阶段药物的详细记录专论。这些专论面向药学与治疗学委员会。订阅者每月还会收到1页关于对议程以及药房/护理在职培训有用药物的简要专论。每月还会提供一份全面的目标药物利用评估/用药使用评估(DUE/MUE)。订阅后,专论会以印刷形式发送,也可在线获取。专论可根据机构需求进行定制。现在每月会随《处方集专论服务》发布一份药物类别综述。通过《处方集》的合作,《医院药学》在本专栏发表精选综述。如需了解《处方集专论服务》的更多信息,请致电《处方集》800 - 322 - 4349。2014年7月的专论主题有阿必鲁肽、雷莫西尤单抗、短豚草花粉变应原提取物、梯牧草花粉变应原提取物和艾沙康唑。DUE/MUE针对阿必鲁肽。

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本文引用的文献

1
Dapagliflozin as monotherapy in drug-naive Asian patients with type 2 diabetes mellitus: a randomized, blinded, prospective phase III study.达格列净单药治疗初治亚洲2型糖尿病患者:一项随机、双盲、前瞻性III期研究。
Clin Ther. 2014 Jan 1;36(1):84-100.e9. doi: 10.1016/j.clinthera.2013.11.002. Epub 2013 Dec 28.
2
Standards of medical care in diabetes--2014.2014年糖尿病医疗护理标准
Diabetes Care. 2014 Jan;37 Suppl 1:S14-80. doi: 10.2337/dc14-S014.
3
Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study.达格列净作为西格列汀联合或不联合二甲双胍的附加疗法是有效的:一项为期 24 周、多中心、随机、双盲、安慰剂对照研究。
Diabetes Care. 2014;37(3):740-50. doi: 10.2337/dc13-0467. Epub 2013 Oct 21.
4
Dapagliflozin treatment for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.达格列净治疗2型糖尿病:一项随机对照试验的系统评价和荟萃分析
Diabetes Metab Res Rev. 2014 Mar;30(3):204-21. doi: 10.1002/dmrr.2479.
5
Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control.对2型糖尿病合并中度肾功能损害患者的长期研究表明,达格列净可减轻体重和降低血压,但不能改善血糖控制。
Kidney Int. 2014 Apr;85(4):962-71. doi: 10.1038/ki.2013.356. Epub 2013 Sep 25.
6
Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years.达格列净用于接受高剂量胰岛素治疗的2型糖尿病患者:两年的疗效和安全性
Diabetes Obes Metab. 2014 Feb;16(2):124-36. doi: 10.1111/dom.12187. Epub 2013 Aug 29.
7
Pharmacokinetic and pharmacodynamic properties of single- and multiple-dose of dapagliflozin, a selective inhibitor of SGLT2, in healthy Chinese subjects.在健康的中国受试者中,达格列净(一种选择性 SGLT2 抑制剂)单次和多次给药的药代动力学和药效学特性。
Clin Ther. 2013 Aug;35(8):1211-1222.e2. doi: 10.1016/j.clinthera.2013.06.017. Epub 2013 Aug 2.
8
Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin.在二甲双胍治疗血糖控制不佳的2型糖尿病患者中,达格列净在2年时间里维持血糖控制,同时减轻体重和体脂量。
Diabetes Obes Metab. 2014 Feb;16(2):159-69. doi: 10.1111/dom.12189. Epub 2013 Aug 29.
9
Urinary tract infections in patients with diabetes treated with dapagliflozin.达格列净治疗糖尿病患者的尿路感染。
J Diabetes Complications. 2013 Sep-Oct;27(5):473-8. doi: 10.1016/j.jdiacomp.2013.05.004. Epub 2013 Jul 10.
10
Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin.达格列净治疗的糖尿病患者的外阴阴道炎和阴茎头炎。
J Diabetes Complications. 2013 Sep-Oct;27(5):479-84. doi: 10.1016/j.jdiacomp.2013.04.012. Epub 2013 Jun 24.