Jegatheeswaran Santhalingam, Jamdar Saurabh, Satyadas Thomas, Sheen Aali J, Adam Rene, Siriwardena Ajith K
Hepato-Pancreato-Biliary Surgery Unit, Manchester Royal Infirmary, Manchester M13 9WL, UK.
Centre Hépato-Biliare, Hôpital Paul-Brousse, 12 Avenue Paul Vaillant Couturier, 94800 Villejuif, France.
HPB Surg. 2014;2014:437159. doi: 10.1155/2014/437159. Epub 2014 Nov 12.
Objectives. This study is a questionnaire survey on the use of pharmacological agents to modify liver ischaemia-reperfusion (IR) injury in patients undergoing hepatectomy for colorectal liver metastases with the target population being those units participating in the LiverMetSurvey international registry. Methods. Members of LiverMetSurvey were sent an online questionnaire using SurveyMonkey comprising ten questions on the use of pharmacological agents to modulate hepatic IR injury in the perioperative period after hepatectomy. The questionnaire was sent to 446 clinicians registered with the LiverMetSurvey. There were 83 (19%) respondents. Results. Fifty-two (77% of 68 respondents to this question) never used pharmacological agents to modify liver IR injury during hepatectomy. Thirteen (19%) used pharmacological agents selectively. Three (4%) used these routinely. N-Acetylcysteine was the most widely used pharmacological agent with equal distribution of use around intraoperative and postoperative periods. Conclusions. This is believed to be the first survey on the use of pharmacological agents to modify liver IR injury. The target population is clinicians involved in liver resection. The results show that pharmacological modulation is used by only a minority of respondents to this questionnaire and that when this treatment is selected, N-acetylcysteine is the most frequently used.
目的。本研究是一项关于在接受结直肠癌肝转移肝切除术的患者中使用药物制剂减轻肝脏缺血再灌注（IR）损伤的问卷调查，目标人群是参与国际肝脏转移瘤调查（LiverMetSurvey）登记处的单位。方法。通过SurveyMonkey向LiverMetSurvey的成员发送一份在线问卷，问卷包含十个关于在肝切除术后围手术期使用药物制剂调节肝脏IR损伤的问题。该问卷发送给了446名在LiverMetSurvey注册的临床医生。有83名（19%）受访者回复。结果。52名（该问题68名受访者中的77%）在肝切除术中从未使用药物制剂减轻肝脏IR损伤。13名（19%）选择性地使用药物制剂。3名（4%）常规使用这些药物。N-乙酰半胱氨酸是使用最广泛的药物制剂，在术中和术后使用分布均等。结论。据信这是首次关于使用药物制剂减轻肝脏IR损伤的调查。目标人群是参与肝切除术的临床医生。结果显示，在本次问卷的受访者中，只有少数人使用药物调节，并且当选择这种治疗时，N-乙酰半胱氨酸是最常使用的。
