Ho Janice D, Tsang James F, Scoggan Kylie A, Leslie William D
University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
Department of Radiology, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
J Thyroid Res. 2014;2014:580569. doi: 10.1155/2014/580569. Epub 2014 Nov 12.
Purpose. To compare iodine clearance following iodinated contrast administration in thyroidectomised thyroid cancer patients and euthyroid individuals. Methods. A convenience population (6 thyroidectomised thyroid cancer patients and 7 euthyroid controls) was drawn from patients referred for iodinated contrast-enhanced computed tomography (CT) studies. Subjects had sequential urine samples collected up to 6 months (50 samples from the thyroidectomised and 63 samples from the euthyroid groups). t-tests and generalised estimating equations (GEE) were used to test for group differences in urinary iodine creatinine ratios. Results. Groups had similar urinary iodine creatinine ratios at baseline, with a large increase 2 weeks following iodinated contrast (P = 0.005). Both groups had a return of urinary iodine creatinine ratios to baseline by 4 weeks, with no significant group differences overall or at any time point. Conclusions. Thyroidectomised patients did not have a significantly different urinary iodine clearance than euthyroid individuals following administration of iodinated contrast. Both had a return of urinary iodine creatinine ratios to baseline within 4 weeks.
目的。比较甲状腺切除术后的甲状腺癌患者和甲状腺功能正常个体在给予碘化造影剂后的碘清除率。方法。从因碘化造影剂增强计算机断层扫描（CT）检查而转诊的患者中选取一个便利样本群体（6例甲状腺切除术后的甲状腺癌患者和7例甲状腺功能正常的对照者）。受试者连续收集尿液样本长达6个月（甲状腺切除组50份样本，甲状腺功能正常组63份样本）。采用t检验和广义估计方程（GEE）来检验尿碘肌酐比值的组间差异。结果。两组在基线时尿碘肌酐比值相似，在给予碘化造影剂后2周大幅升高（P = 0.005）。两组的尿碘肌酐比值在4周时均恢复至基线水平，总体及任何时间点均无显著组间差异。结论。甲状腺切除术后患者在给予碘化造影剂后，其尿碘清除率与甲状腺功能正常个体相比无显著差异。两者的尿碘肌酐比值均在4周内恢复至基线水平。
