单瓶冻干TRODAT-1试剂盒：[(99m)Tc]TRODAT-1在印度情况下的制备及临床疗效验证
Single vial freeze-dried TRODAT-1 kit: preparation and demonstration of clinical efficacy of [(99m)Tc]TRODAT-1 in Indian scenario.
作者信息
Korde Aruna, Kameswaran Mythili, Satpati Drishty, Dev Sarma Haladhar, Banerjee Sharmila, Shinto Ajit, Kamaleshwaran K K, Samuel Grace
机构信息
Isotope Applications & Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India.
出版信息
Appl Radiat Isot. 2015 Feb;96:57-62. doi: 10.1016/j.apradiso.2014.10.017. Epub 2014 Nov 12.
A single vial freeze-dried kit formulation for preparation of three patients' dose of [(99m)Tc]TRODAT-1 has been developed for early diagnosis of Parkinson's disease (PD). Kits were evaluated to ascertain the purity, stability and batch to batch variations. Preclinical evaluation was carried out in laboratory animals and clinical imaging was performed in human patients with PD. The labeling yield and purity of [(99m)Tc]TRODAT-1 was >90%. Swiss mice showed retention of [(99m)Tc]TRODAT-1 in the mid brain region. Clinical studies showed decreased striatal uptake with increasing severity of PD.
已开发出一种单瓶冻干试剂盒配方，用于制备三剂患者剂量的[(99m)Tc]TRODAT-1，用于帕金森病（PD）的早期诊断。对试剂盒进行了评估，以确定其纯度、稳定性和批次间差异。在实验动物中进行了临床前评估，并在PD患者中进行了临床成像。[(99m)Tc]TRODAT-1的标记产率和纯度>90%。瑞士小鼠显示[(99m)Tc]TRODAT-1在中脑区域有滞留。临床研究表明，随着PD严重程度的增加，纹状体摄取减少。
Zotero 插件