[99mTc]TRODAT-1单光子发射计算机断层扫描成像在早期帕金森病中的诊断准确性
Diagnostic accuracy of [99mTc]TRODAT-1 SPECT imaging in early Parkinson's disease.
作者信息
Chou K L, Hurtig H I, Stern M B, Colcher A, Ravina B, Newberg A, Mozley P D, Siderowf A
机构信息
Parkinson's Disease and Movement Disorders Center, University of Pennsylvania School of Medicine, Pennsylvania Hospital, 330 South Ninth Street, Philadelphia, PA 19107, USA.
出版信息
Parkinsonism Relat Disord. 2004 Aug;10(6):375-9. doi: 10.1016/j.parkreldis.2004.04.002.
We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and anterior and posterior putamen (p < 0.0001) of PD patients compared to controls. Using the posterior putamen as the main region of interest resulted in the greatest accuracy (sensitivity 0.79, specificity 0.92). These findings show that TRODAT imaging can accurately differentiate early PD patients from controls and has the potential to improve the diagnosis of patients with early signs of PD.
我们评估了使用[（99m）Tc]TRODAT-1（TRODAT，一种相对便宜的锝标记多巴胺转运体配体）的单光子发射计算机断层显像（SPECT）成像在区分29例早期帕金森病（PD）患者和38名健康志愿者方面的诊断准确性。与对照组相比，PD患者尾状核（p = 0.0097）以及壳核前、后部（p < 0.0001）的TRODAT摄取均值显著降低。以壳核后部作为主要感兴趣区域时准确性最高（敏感性0.79，特异性0.92）。这些发现表明，TRODAT成像能够准确区分早期PD患者与对照组，并且有可能改善具有PD早期体征患者的诊断。
Zotero 插件