沉睡的美人唤醒了稳态造血的克隆连续性模型。
Sleeping beauty wakes up the clonal succession model for homeostatic hematopoiesis.
机构信息
Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, 1425 San Pablo Street, Los Angeles, CA 90033, USA.
出版信息
Cell Stem Cell. 2014 Dec 4;15(6):677-8. doi: 10.1016/j.stem.2014.11.015.
Recently in Nature, Sun et al. (2014) used a sleeping beauty transposon system to demonstrate that natural hematopoiesis is sustained by the successive recruitment of thousands of clones that are mostly lineage restricted. These findings call into question whether homeostatic hematopoiesis is sustained by hematopoietic stem cells traditionally identified by transplantation.
最近，孙等人（2014 年）在《自然》杂志上发表文章，利用睡眠美人转座子系统表明，天然造血是由数千个克隆的连续募集来维持的，这些克隆大多数是谱系受限的。这些发现质疑了传统上通过移植鉴定的造血干细胞是否维持了稳态造血。
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