Wu Chiao-En, Wang Chi-Wei, Huang Wen-Kuan, Yang Cheng-Ta, Wu Yi-Cheng, Hou Ming-Mo, Hsieh Chia-Hsun, Hsieh Jia-Juan, Cheng Hsin-Yi, Hsu Todd, Chang John Wen-Cheng
Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan Chang Gung University College of Medicine, Taoyuan.
Chang Gung University College of Medicine, Taoyuan Department of Pathology, Chang Gung Memorial Hospital, Taoyuan.
Jpn J Clin Oncol. 2015 Mar;45(3):267-73. doi: 10.1093/jjco/hyu202. Epub 2014 Dec 5.
Parathyroid hormone-like related protein was a prognostic factor for non-small-cell lung cancer, but the results were conflicting. The present study was to examine the role of cytoplasmic and nuclear parathyroid hormone-like related protein in patients with non-small-cell lung cancer who have undergone surgical therapy.
The expression of parathyroid hormone-like related protein was examined by immunohistochemical staining in 56 patients with resectable non-small-cell lung cancer. The impact of parathyroid hormone-like related protein expression on cancer recurrence and survival was assessed in combination with clinicopathologic features.
Patients with a high expression of cytoplasmic parathyroid hormone-like related protein had a significantly unfavorable prognosis in both disease-free survival (median 16.7 vs. 58.0 months, P = 0.029) and overall survival (median 31.6 months vs. not reached, P = 0.046). In contrast, the patients with high expression of nuclear parathyroid hormone-like related protein had favorable disease-free survival (median 35.1 vs. 19.9 months, P = 0.069) and a significantly better overall survival (median not reached vs. 36.9 months, P = 0.033). There was no correlation between the expression of cytoplasmic and nuclear parathyroid hormone-like related protein (P = 1.00). Furthermore, multivariate analysis using a Cox regression model confirmed that high expression of cytoplasmic parathyroid hormone-like related protein (disease-free survival, hazard ratio: 1.973, P = 0.079; overall survival, hazard ratio: 2.461, P = 0.067) and nuclear parathyroid hormone-like related protein (disease-free survival, hazard ratio: 0.436, P = 0.029; overall survival, hazard ratio: 0.375, P = 0.018) were independently prognostic factors for disease-free survival and overall survival.
Cytoplasmic and nuclear parathyroid hormone-like related protein play opposing prognostic roles for the disease-free survival and overall survival of patients with early non-small-cell lung cancer who have undergone curative resection.
甲状旁腺激素样相关蛋白是非小细胞肺癌的一个预后因素，但结果存在矛盾。本研究旨在探讨细胞质和细胞核甲状旁腺激素样相关蛋白在接受手术治疗的非小细胞肺癌患者中的作用。
采用免疫组织化学染色法检测56例可切除的非小细胞肺癌患者甲状旁腺激素样相关蛋白的表达。结合临床病理特征评估甲状旁腺激素样相关蛋白表达对癌症复发和生存的影响。
细胞质甲状旁腺激素样相关蛋白高表达的患者在无病生存期（中位生存期16.7个月对58.0个月，P = 0.029）和总生存期（中位生存期31.6个月对未达到，P = 0.046）方面预后均明显较差。相比之下，细胞核甲状旁腺激素样相关蛋白高表达的患者无病生存期良好（中位生存期35.1个月对19.9个月，P = 0.069），总生存期明显更好（中位生存期未达到对36.9个月，P = 0.033）。细胞质和细胞核甲状旁腺激素样相关蛋白的表达之间无相关性（P = 1.00）。此外，使用Cox回归模型进行的多因素分析证实，细胞质甲状旁腺激素样相关蛋白高表达（无病生存期，风险比：1.973，P = 0.079；总生存期，风险比：2.461，P = 0.067）和细胞核甲状旁腺激素样相关蛋白高表达（无病生存期，风险比：0.436，P = 0.029；总生存期，风险比：0.375，P = 0.018）是无病生存期和总生存期的独立预后因素。
细胞质和细胞核甲状旁腺激素样相关蛋白对接受根治性切除的早期非小细胞肺癌患者的无病生存期和总生存期起着相反的预后作用。
