芝麻开门：癌症治疗中储存式钙内流途径的宝藏
Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy.
作者信息
Pan Zui, Ma JianJie
机构信息
Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA,
出版信息
Sci China Life Sci. 2015 Jan;58(1):48-53. doi: 10.1007/s11427-014-4774-3. Epub 2014 Dec 7.
Abstract
Store-operated Ca(2+) entry (SOCE) controls intracellular Ca(2+) homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment.
摘要
储存性钙内流（SOCE）控制细胞内钙稳态，并调节包括增殖、迁移和侵袭在内的广泛细胞事件。STIM蛋白作为钙传感器以及Orai蛋白作为钙通道孔形成单位的发现，为理解SOCE的生理功能提供了分子工具。许多研究揭示了Orai和STIM在肿瘤细胞中的病理生理作用。本综述重点关注SOCE的最新进展及其对肿瘤发生的贡献。Orai和/或STIM功能的改变可能作为癌症预后的生物标志物，而靶向SOCE途径可能为癌症治疗提供一种新方法。
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