[宫内生长受限中脐血管的病理生理变化]
[Pathophysiological changes of umbilical vessels in intrauterine growth restriction].
作者信息
Jakó Mária, Surányi Andrea, Kaiser László, Domokos Dóra, Gáspár Róbert, Bártfai György
机构信息
Szegedi Tudományegyetem, Általános Orvostudományi Kar Szülészeti és Nőgyógyászati Klinika Szeged Semmelweis u. 1. 6725.
Szegedi Tudományegyetem, Általános Orvostudományi Kar Patológiai Intézet Szeged.
出版信息
Orv Hetil. 2014 Dec 14;155(50):1989-95. doi: 10.1556/OH.2014.30003.
INTRODUCTION
The prevalence of intrauterine growth restriction is 4-5000/100,000 births, and they give the majority of perinatal morbidity.
AIM
The aim of the authors was to compare the pathomorphologic data and vasoreactivity of umbilical vessels and placenta of small for date newborns to that of the normal pregnancies.
METHOD
Samples of the umbilical cord and placenta were divided into case and control groups. Two 10 cm long segments were cut of the umbilical cord at placental insertion. Tissue bath experiment was performed on umbilical vessels and pathomorphologic data were collected according to the Royal College of Pathologists' protocol.
RESULTS
After the development of basal tone, oxytocin and desmopressin did not enhance the vascular contraction, but the pathomorphological and ultrasonographic data were significantly different in the two groups.
CONCLUSIONS
The results indicate that umbilical vessels might not have oxytocin or vasopressin receptors. The pathomorphologic and flowmetric differences could be the causes of small birth weight.
引言
宫内生长受限的发生率为每10万例出生中有4 - 5000例，且它们导致了大多数围产期发病情况。
目的
作者的目的是比较足月小样儿新生儿的脐带和胎盘的病理形态学数据以及脐血管的血管反应性与正常妊娠的情况。
方法
将脐带和胎盘样本分为病例组和对照组。在胎盘附着处切取两段10厘米长的脐带。对脐血管进行组织浴实验，并根据皇家病理学家学院的方案收集病理形态学数据。
结果
在基础张力形成后，催产素和去氨加压素并未增强血管收缩，但两组的病理形态学和超声数据存在显著差异。
结论
结果表明脐血管可能没有催产素或血管加压素受体。病理形态学和血流测量差异可能是出生体重低的原因。
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