Bruch J F, Sibony O, Benali K, Challier J C, Blot P, Nessmann C
Laboratoire TIMC-CNRS-IMAG (UMR 5525), Institut Albert Bonniot, La Tronche, France.
Hum Pathol. 1997 Oct;28(10):1139-45. doi: 10.1016/s0046-8177(97)90251-3.
Computerized microscope morphometry was used to study cross sections from the vessels of the umbilical cord in placentas of patients with intrauterine growth retardation (IUGR) that displayed either normal or abnormal umbilical arteries (UA) Doppler flow velocity waveforms (FVW). Cords from 63 eutrophic fetuses with normal Doppler (controls), 47 IUGR fetuses with normal Doppler and 32 IUGR fetuses with abnormal Doppler underwent morphometric analysis using a highly optimized microscope environment (HOME) and "CordHOME" software. IUGR with an accompanying normal Doppler versus control showed a reduction of Wharton jelly and both the total and lumen vein areas. IUGR with an accompanying pathological Doppler showed a comparable reduction in wall thickness and areas of every vessel. These findings indicate that the hypoplastic umbilical vessels are associated with an increase in placental vascular resistance that may be the consequence of underdevelopment in response to a chronic reduction in placental blood flow.
采用计算机显微镜形态测定法，对宫内生长受限（IUGR）患者胎盘脐带血管的横断面进行研究，这些患者的脐动脉（UA）多普勒血流速度波形（FVW）显示正常或异常。对63例多普勒正常的营养良好胎儿（对照组）、47例多普勒正常的IUGR胎儿和32例多普勒异常的IUGR胎儿的脐带，使用高度优化的显微镜环境（HOME）和“CordHOME”软件进行形态分析。伴有正常多普勒的IUGR与对照组相比，华通胶以及静脉总面积和管腔面积均减少。伴有病理性多普勒的IUGR显示，各血管的壁厚和面积有类似程度的减少。这些发现表明，脐血管发育不全与胎盘血管阻力增加有关，这可能是胎盘血流长期减少导致发育不全的结果。
