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刺苍耳中苍耳素的提取优化及其细胞毒性、抗血管生成和抗病毒特性

Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties.

作者信息

Romero M, Zanuy M, Rosell E, Cascante M, Piulats J, Font-Bardia M, Balzarini J, De Clerq E, Pujol M D

机构信息

Laboratory of Pharmaceutical Chemistry (associated to CSIC), Faculty of Pharmacy, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.

出版信息

Eur J Med Chem. 2015 Jan 27;90:491-6. doi: 10.1016/j.ejmech.2014.11.060. Epub 2014 Dec 1.

DOI:10.1016/j.ejmech.2014.11.060
PMID:25481815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7115430/
Abstract

The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.

摘要

从刺苍耳（Xanthium spinosum L.）中对倍半萜内酯苍耳素进行水提取，有利于通过乙酸的损失将苍耳宁（1）转化为苍耳素（2）。已确定分离出的苍耳素的细胞毒性（Hep-G2和L1210人细胞系）和抗病毒活性。这种天然化合物对Hep-G2细胞系显示出显著的细胞毒性，我们的实验结果揭示了其在体外具有强大的抗血管生成能力。苍耳素的结构通过光谱方法确定，并首次通过X射线衍射得到证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/5e8012cc69d3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/224a58e3fff9/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/1da81ff99916/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/20f9bec50286/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/3ab0088401f2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/94ebf203d7c4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/5e8012cc69d3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/224a58e3fff9/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/1da81ff99916/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/20f9bec50286/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/3ab0088401f2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/94ebf203d7c4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4709/7115430/5e8012cc69d3/gr5.jpg

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