刺苍耳中苍耳素的提取优化及其细胞毒性、抗血管生成和抗病毒特性

Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties.

作者信息

Romero M, Zanuy M, Rosell E, Cascante M, Piulats J, Font-Bardia M, Balzarini J, De Clerq E, Pujol M D

机构信息

Laboratory of Pharmaceutical Chemistry (associated to CSIC), Faculty of Pharmacy, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.

出版信息

Eur J Med Chem. 2015 Jan 27;90:491-6. doi: 10.1016/j.ejmech.2014.11.060. Epub 2014 Dec 1.

The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.