通过立体选择性大岛-内本反应不对称合成(-)-二氢山苍子素。

Asymmetric synthesis of (-)-dihydroxanthatin by the stereoselective Oshima-Utimoto reaction.

作者信息

Evans Michael A, Morken James P

机构信息

Department of Chemistry, The University of North Carolina at Chapel Hill, 27599-3290, USA.

出版信息

Org Lett. 2005 Jul 21;7(15):3371-3. doi: 10.1021/ol051276k.

DOI:10.1021/ol051276k

PMID:16018663

Abstract

[reaction: see text]. The catalytic stereoselective Oshima-Utimoto reaction is useful for the construction of five-membered oxacycles from simple starting materials and was employed for the preparation of the lactone group in the asymmetric synthesis of (-)-11alpha,13-dihydroxanthatin. Completion of the synthesis is facilitated by ring-closing enyne metathesis and alkene cross metathesis reactions.

摘要

[反应：见正文]。催化立体选择性大岛-宇本反应可用于从简单起始原料构建五元氧杂环，并用于在（-）-11α，13-二氢山金车素的不对称合成中制备内酯基团。闭环烯炔复分解反应和烯烃交叉复分解反应有助于合成的完成。