ADRBK1、AKT3、ATF3、DIO2、TBXA2R和VEGFA中的调控单核苷酸多态性及转录因子结合位点
Regulatory SNPs and transcriptional factor binding sites in ADRBK1, AKT3, ATF3, DIO2, TBXA2R and VEGFA.
作者信息
Buroker Norman E
机构信息
a Department of Pediatrics , University of Washington , Seattle , WA USA.
出版信息
Transcription. 2014;5(4):e964559. doi: 10.4161/21541264.2014.964559. Epub 2014 Oct 31.
Abstract
Abstract Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the ADRBK1 (GRK2), AKT3, ATF3, DIO2, TBXA2R and VEGFA genes. Changes in the TFBS where TFs attach to regulate these genes may result in human sickness and disease. The highlights of this previous work were reviewed for these genes.
摘要
摘要 对ADRBK1（GRK2）、AKT3、ATF3、DIO2、TBXA2R和VEGFA基因的调控单核苷酸多态性（rSNP）进行了综述，这些多态性改变了转录因子（TF）与DNA结合的转录因子结合位点（TFBS）。TF与这些基因结合以进行调控的TFBS发生变化可能会导致人类疾病。本文回顾了此前针对这些基因的研究要点。
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