减毒活的红前期疟疾疫苗。
Live attenuated pre-erythrocytic malaria vaccines.
机构信息
a Seattle Biomedical Research Institute ; Seattle , WA USA.
出版信息
Hum Vaccin Immunother. 2014;10(10):2903-9. doi: 10.4161/21645515.2014.972764.
Abstract
Although recent control measures have significantly reduced malaria cases and deaths in many endemic areas, an effective vaccine will be essential to eradicate this parasitic disease. Malaria vaccine strategies developed to date focus on different phases of the parasite's complex life cycle in the human host and mosquito vector, and include both subunit-based and whole-parasite vaccines. This review focuses on the 3 live-attenuated malaria vaccination strategies that have been tested in humans to date, and discusses their progress, challenges and the immune correlates of protection that have been identified.
摘要
尽管最近的控制措施已经大大减少了许多流行地区的疟疾病例和死亡人数，但要消灭这种寄生虫病，有效的疫苗将是必不可少的。迄今为止开发的疟疾疫苗策略侧重于寄生虫在人类宿主和蚊子媒介中的复杂生命周期的不同阶段，包括基于亚单位和全寄生虫疫苗。这篇综述重点介绍了迄今为止在人类中测试过的 3 种减毒疟疾疫苗接种策略，并讨论了它们的进展、挑战以及已确定的保护免疫相关性。
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