Ferrari R P, Paradisi L, Torrielli M
Dipartimento di Chimica Inorganica, Università di Torino, Italy.
Anticancer Res. 1989 May-Jun;9(3):771-3.
Modifications of serum levels of iron transferrin and copper ceruloplasmin after acute inflammation by carrageenan and treatment with acetyl salicylic acid [ASA] or Cu(II)2(acetylsalicylate)4 [Cu(II)2(AS)4] were studied in the rat by EPR spectroscopy. Furthermore, the ulcerogenic potential of the two drugs was investigated after a single high oral dose. Our results indicate that Cu(II)2(AS)4 is more effective than ASA in limiting the inflammation provoked by the phlogogen. In these conditions the iron(III) non-heme and copper(II) ceruloplasmin concentration in serum was modified either during inflammation or after treatment with antiphlogistic agents: in carrageenan-injected rats the level of serum iron(III) non-heme was found to be very low, while the copper(II) ceruloplasmin concentration was partially reduced. On the other hand, after the pharmacological treatments, no changes of iron transferrin were observed and the concentration of copper ceruloplasmin was increased. With regard to their ulcerogenic effect, ASA appeared to be more irritating for gastric mucosa than Cu(II)2(AS)4.
通过电子顺磁共振光谱法在大鼠中研究了角叉菜胶引发急性炎症后血清中铁传递蛋白和铜蓝蛋白水平的变化，以及用乙酰水杨酸[ASA]或Cu(II)2(乙酰水杨酸)4 [Cu(II)2(AS)4]治疗后的情况。此外，在单次高剂量口服后研究了这两种药物的致溃疡潜力。我们的结果表明，Cu(II)2(AS)4在限制促炎剂引发的炎症方面比ASA更有效。在这些情况下，血清中的非血红素铁(III)和铜(II)铜蓝蛋白浓度在炎症期间或用抗炎剂治疗后会发生改变：在注射角叉菜胶的大鼠中，发现血清非血红素铁(III)水平非常低，而铜(II)铜蓝蛋白浓度部分降低。另一方面，经过药物治疗后，未观察到铁传递蛋白的变化，铜蓝蛋白浓度增加。关于它们的致溃疡作用，ASA对胃黏膜的刺激性似乎比Cu(II)2(AS)4更大。
