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奥硝唑所致固定性药疹。

Fixed drug eruption due to ornidazole.

作者信息

Gupta Ramji

机构信息

Department of Dermatology, Indraprastha Apollo Hospital Sarita Vihar, New Delhi, India.

出版信息

Indian J Dermatol. 2014 Nov;59(6):635. doi: 10.4103/0019-5154.143591.

DOI:10.4103/0019-5154.143591
PMID:25484435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4248543/
Abstract

A 56-year-old male developed an ulcer on his glans penis and mucosae of upper and lower lips 3 days after taking ofloxacin, cephalexin, and ornidazole. Clinically, a provisional diagnosis of fixed drug eruption was made. The causative drug was confirmed by an oral provocation test which triggered a reactivation of all lesions only with ornidazole.

摘要

一名56岁男性在服用氧氟沙星、头孢氨苄和奥硝唑3天后,阴茎龟头及上下唇黏膜出现溃疡。临床上初步诊断为固定性药疹。通过口服激发试验确诊致病药物,该试验仅用奥硝唑就引发了所有皮损的复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf4/4248543/fd0f2959aea8/IJD-59-635a-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf4/4248543/fd0f2959aea8/IJD-59-635a-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdf4/4248543/fd0f2959aea8/IJD-59-635a-g001.jpg

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本文引用的文献

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Fixed Drug Eruptions in a 9 Months Old Child.一名9个月大儿童的固定性药疹
Indian J Dermatol Venereol Leprol. 1989 May-Jun;55(3):181-192.
2
Zosteriform fixed drug eruption to levofloxacin.左氧氟沙星所致的带状固定性药疹。
Indian J Dermatol. 2012 Jul;57(4):327-8. doi: 10.4103/0019-5154.97688.
3
Mucosal fixed drug eruption in a patient treated with ornidazole.一名接受奥硝唑治疗的患者发生黏膜固定性药疹。
J Dermatol Case Rep. 2012 Mar 27;6(1):21-4. doi: 10.3315/jdcr.2012.1091.
4
Multiple fixed drug eruption caused by ornidazole.奥硝唑引起的多发性固定性药疹。
Dermatitis. 2010 Nov-Dec;21(6):330-3.
5
Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.奥硝唑所致固定性药疹对塞克硝唑存在交叉敏感性,但对其他硝基咪唑类化合物无交叉敏感性:1例病例报告
Br J Clin Pharmacol. 2010 Jun;69(6):703-4. doi: 10.1111/j.1365-2125.2010.03651.x.
6
Regularity of recurrence of fixed drug eruption: a pointer to the cause.固定性药疹复发规律:病因线索
Indian J Dermatol. 2009;54(2):188. doi: 10.4103/0019-5154.53176.
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Multifocal bullous fixed drug eruption due to fluconazole.氟康唑引起的多灶性大疱性固定性药疹。
Indian J Dermatol. 2008;53(3):156-7. doi: 10.4103/0019-5154.43212.
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Azithromycin in acne: a protagonist for fixed drug reaction?阿奇霉素治疗痤疮:固定性药疹的诱因?
Indian J Dermatol. 2008;53(2):100-1. doi: 10.4103/0019-5154.41661.
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Fixed drug eruption: pathogenesis and diagnostic tests.固定型药物疹:发病机制与诊断检测。
Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):316-21. doi: 10.1097/ACI.0b013e32832cda4c.
10
Drugs causing fixed drug eruptions: confirmed by provocation tests.
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