耳蜗外毛细胞中离子转运和渗透体积控制的模型。
A model of ionic transport and osmotic volume control in cochlear outer hair cells.
机构信息
UCL Ear Institute , 332 Gray's Inn Road, London WC1X 8EE , UK.
UCL Ear Institute , 332 Gray's Inn Road, London WC1X 8EE , UK ; Department of Neuroscience, Physiology and Pharmacology , UCL , Gower St., London WC1E 6BT , UK.
出版信息
Interface Focus. 2014 Dec 6;4(6):20140018. doi: 10.1098/rsfs.2014.0018.
A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membrane of OHCs. A model of intracellular pH transients following the imposition of a rapid acid load upon the cell has been adapted from the squid axon literature and further extended in order to investigate the effects of ion transport upon the osmotic flux of water into the cell. The model predicts the slow length changes of OHCs reported in the literature a feature which may control the contribution of OHCs to cochlear amplification.
本文提出了一个哺乳动物耳蜗外毛细胞（OHC）的计算模型。它探讨了离子运动如何控制细胞形状并调节 pH 值。该模型考虑了 prestin 的氯离子-碳酸氢盐交换功能，该蛋白在 OHC 质膜中高度表达。根据鱿鱼轴突文献改编了细胞内 pH 瞬变模型，以研究离子运输对水进入细胞的渗透通量的影响。该模型预测了文献中报道的 OHC 缓慢的长度变化，这一特征可能控制了 OHC 对耳蜗放大的贡献。
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