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使用眼前节光学相干断层扫描和共聚焦显微镜对两种不同方案的加速角膜胶原交联术后角膜基质分界线的评估。

Evaluation of corneal stromal demarcation line after two different protocols of accelerated corneal collagen cross-linking procedures using anterior segment optical coherence tomography and confocal microscopy.

作者信息

Ozgurhan Engin Bilge, Sezgin Akcay Betul Ilkay, Yildirim Yusuf, Karatas Gonul, Kurt Tugba, Demirok Ahmet

机构信息

Department of Ophthalmology, Beyoglu Eye Training and Research Hospital, Bereketzade Camii Sok, Kuledibi, Beyoglu, 34421 Istanbul, Turkey.

Department of Ophthalmology, Umraniye Training and Research Hospital, Istanbul, Turkey.

出版信息

J Ophthalmol. 2014;2014:981893. doi: 10.1155/2014/981893. Epub 2014 Nov 18.

DOI:10.1155/2014/981893
PMID:25485145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4251080/
Abstract

Purpose. To evaluate the depth of corneal stromal demarcation line using AS-OCT and confocal microscopy after two different protocols of accelerated corneal collagen cross-linking procedures (CXL). Methods. Patients with keratoconus were divided into two groups. Peschke CXL device (Peschke CCL-VARIO Meditrade GmbH) applied UVA light with an intended irradiance of 18.0 mW/cm(2) for 5 minutes after applying riboflavin for 20 minutes (group 1) and 30 minutes (group 2). One month postoperatively, corneal stromal demarcation line was measured using AS-OCT and confocal microscopy. Results. This study enrolled 34 eyes of 34 patients (17 eyes in group 1 and 17 eyes in group 2). The mean depth of the corneal stromal demarcation line was 208.64 ± 18.41 μm in group 1 and 240.37 ± 18.89 μm in group 2 measured with AS OCT, while it was 210.29 ± 18.66 μm in group 1 and 239.37 ± 20.07 μm in group 2 measured with confocal microscopy. Corneal stromal demarcation line depth measured with AS OCT or confocal microscopy was significantly deeper in group 2 than group 1 (P < 0.01). Conclusion. The group in which riboflavin was applied for 30 minutes showed significantly deeper corneal stromal demarcation line than the group in which riboflavin was applied for 20 minutes.

摘要

目的。在两种不同的加速角膜胶原交联程序（CXL）方案后，使用眼前节光学相干断层扫描（AS - OCT）和共聚焦显微镜评估角膜基质分界线的深度。方法。圆锥角膜患者被分为两组。在应用核黄素20分钟（第1组）和30分钟（第2组）后，使用Peschke CXL设备（Peschke CCL - VARIO Meditrade GmbH）以预期辐照度18.0 mW/cm²施加紫外线A光5分钟。术后1个月，使用AS - OCT和共聚焦显微镜测量角膜基质分界线。结果。本研究纳入了34例患者的34只眼（第1组17只眼，第2组17只眼）。用AS - OCT测量时，第1组角膜基质分界线的平均深度为208.64±18.41μm，第2组为240.37±18.89μm；用共聚焦显微镜测量时，第1组为210.29±18.66μm，第2组为239.37±20.07μm。用AS - OCT或共聚焦显微镜测量的角膜基质分界线深度在第2组显著深于第1组（P < 0.01）。结论。应用核黄素30分钟的组比应用核黄素20分钟的组角膜基质分界线明显更深。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ed/4251080/338057e1fd19/JOPH2014-981893.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ed/4251080/74f2bea3e292/JOPH2014-981893.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ed/4251080/338057e1fd19/JOPH2014-981893.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ed/4251080/74f2bea3e292/JOPH2014-981893.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73ed/4251080/338057e1fd19/JOPH2014-981893.002.jpg

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Accelerated versus conventional corneal collagen crosslinking.加速与传统角膜胶原交联
J Cataract Refract Surg. 2014 Jun;40(6):1013-20. doi: 10.1016/j.jcrs.2013.12.012.
3
Corneal stroma demarcation line after standard and high-intensity collagen crosslinking determined with anterior segment optical coherence tomography.
Front Med (Lausanne). 2023 Jun 20;10:1212314. doi: 10.3389/fmed.2023.1212314. eCollection 2023.
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Accelerated epithelium-on or accelerated epithelium-off corneal collagen cross-linking: Contralateral comparison study.加速上皮在位或加速上皮脱失的角膜胶原交联：对侧比较研究。
Taiwan J Ophthalmol. 2020 Mar 4;10(1):37-44. doi: 10.4103/tjo.tjo_11_19. eCollection 2020 Jan-Mar.
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Three-year follow-up of accelerated transepithelial corneal cross-linking for progressive paediatric keratoconus.加速经上皮角膜交联术治疗进行性儿童圆锥角膜的三年随访。
Br J Ophthalmol. 2020 Nov;104(11):1608-1612. doi: 10.1136/bjophthalmol-2019-315260. Epub 2020 Feb 12.
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