From the Department of Biotechnology and Medical-Surgical Sciences, Sapienza University of Rome, Terracina (Latina), Italy.
From the Department of Biotechnology and Medical-Surgical Sciences, Sapienza University of Rome, Terracina (Latina), Italy.
J Cataract Refract Surg. 2018 May;44(5):596-602. doi: 10.1016/j.jcrs.2018.02.017.
To use anterior segment optical coherence tomography (AS-OCT) to compare corneal stromal demarcation line depth after 4 treatment protocols of corneal crosslinking (CXL).
Eye Clinic, Sapienza University of Rome, Terracina (Latina), Italy.
Prospective case series.
Patients with progressive keratoconus were delegated to one of the following CXL treatments: (1) conventional epithelium (epi)-off 3 mW/cm according to the standard Dresden protocol (C-CXL group), (2) accelerated epi-off 10 mW/cm (A-CXL group), (3) transepithelial epi-on 3 mW/cm (TE-CXL group), or (4) transepithelial epi-on by iontophoresis 10 mW/cm (I-CXL group). Two independent observers measured the corneal stromal demarcation line using AS-OCT.
The study comprised 70 patients (120 eyes, 30 eyes in each group). The corneal stromal demarcation line was identified on AS-OCT scans in 109 eyes (90.8%). One month after the treatment, the mean stromal demarcation line depth was 275.05 μm ± 41.83 (SD) in the C-CXL group, 279.35 ± 33.07 μm in the A-CXL group, 132.60 ± 22.14 μm in the TE-CXL group, and 235.40 ± 37.08 μm in the I-CXL group. The difference in stromal demarcation line depth was not statistically significant between the C-CXL and A-CXL group, but it was statistically significant (P < .05) between the epi-off and epi-on CXL groups and between the 2 epi-on groups, where the demarcation line was significantly deeper in the I-CXL group than in the TE-CXL group.
The corneal stromal demarcation line was significantly deeper after epi-off 30-minute standard CXL treatment and after epi-off 9-minute accelerated CXL with high-intensity ultraviolet-A irradiation.
使用眼前节光学相干断层扫描（AS-OCT）比较 4 种角膜交联（CXL）治疗方案后角膜基质分界线深度。
意大利罗马萨皮恩扎大学特兰奇纳（拉蒂纳）眼科诊所。
前瞻性病例系列。
将进展性圆锥角膜患者分为以下 4 种 CXL 治疗之一：（1）标准德累斯顿方案的常规上皮（epi）-off 3 mW/cm（C-CXL 组），（2）加速 epi-off 10 mW/cm（A-CXL 组），（3）上皮内 3 mW/cm 的经上皮（TE-CXL 组），或（4）上皮内 10 mW/cm 的离子电渗疗法（I-CXL 组）。两名独立观察者使用 AS-OCT 测量角膜基质分界线。
该研究纳入了 70 例患者（120 只眼，每组 30 只眼）。在 109 只眼中（90.8%）AS-OCT 扫描中可识别角膜基质分界线。治疗后 1 个月，C-CXL 组基质分界线深度的平均值为 275.05 ± 41.83 μm（标准差），A-CXL 组为 279.35 ± 33.07 μm，TE-CXL 组为 132.60 ± 22.14 μm，I-CXL 组为 235.40 ± 37.08 μm。C-CXL 组和 A-CXL 组的基质分界线深度差异无统计学意义，但 epi-off 和 epi-on CXL 组之间以及 2 个 epi-on 组之间的差异有统计学意义（P <.05），其中 I-CXL 组的分界线明显比 TE-CXL 组深。
30 分钟标准 epi-off CXL 治疗和高强度紫外线-A 照射下的 9 分钟 epi-off 加速 CXL 后，角膜基质分界线明显更深。
