Steenbeck L, Jacobasch K H
Zentralinstitut für Krebsforschung der Akademie der Wissenschaften, DDR, Berlin-Buch.
Gastroenterol J. 1989;49(1):29-31.
In connection with routine endoscopic examinations of 31 patients with familial adenomatosis coli and 28 healthy kindreds of patients with familial adenomatosis coli we investigated by autoradiography the in vitro incorporation of 3H-thymidine into bioptic mucosal particles from colon and adenomas. Within the 5-year follow-up period there was found a significantly increased labelling index of polyps and the surrounding mucosa in patients with polyposis independing on the time elapsed after operation. In 12 of 28 kindreds the histological normal colonic mucosa showed an increased labelling index too. The prognostic value of these results must be proved by further controls.
结合对31例家族性腺瘤性息肉病患者和28例家族性腺瘤性息肉病患者的健康亲属进行的常规内镜检查，我们通过放射自显影术研究了³H-胸腺嘧啶核苷在来自结肠和腺瘤的活检黏膜颗粒中的体外掺入情况。在5年的随访期内，发现息肉病患者的息肉及周围黏膜的标记指数显著增加，且与术后经过的时间无关。在28个亲属组中的12个中，组织学正常的结肠黏膜的标记指数也有所增加。这些结果的预后价值必须通过进一步的对照研究来证实。
