微小RNA特征凸显出新的乳腺癌亚型。

MicroRNA signatures highlight new breast cancer subtypes.

作者信息

Bhattacharyya Malay, Nath Joyshree, Bandyopadhyay Sanghamitra

机构信息

Department of Information Technology, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, India.

Machine Intelligence Unit, Indian Statistical Institute, Kolkata 700108, India.

出版信息

Gene. 2015 Feb 10;556(2):192-8. doi: 10.1016/j.gene.2014.11.053. Epub 2014 Dec 5.

DOI:10.1016/j.gene.2014.11.053

PMID:25485717

Abstract

MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development. Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim.

摘要

微小RNA（miRNA）是一类短的非编码RNA，长度约为22个核苷酸，它们可调节并有时降解靶标信使核糖核酸（mRNA），从而调控多种细胞功能。该领域的最新研究证实了miRNA参与各种疾病进展，包括某些类型癌症的发展。此外，miRNA的全基因组表达谱已被证明有助于区分各种癌症类型。在本文中，我们使用了大量乳腺癌肿瘤样本的miRNA表达谱来识别乳腺癌的亚型。实验结果表明，miRNA具有区分癌症亚型的独特特征，并揭示了新的癌症亚型。基于临床数据的额外生存分析也支持了这一观点。